[Pro9] Substance P is a modified analog of Substance P with proline (Pro) substituted at position 9, replacing the native glycine (Gly). This structural modification enhances stability and resistance to enzymatic degradation while optimizing binding affinity for neurokinin-1 (NK-1) receptors. It retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, this analog aids in investigating structure-activity relationships and exploring therapeutic potential for analgesic and anti-inflammatory applications.
Chemical Formula: C66H102N18O13S
Molecular Weight: 1387.73
Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Pro-Leu-Met-NH2
Purity: From crude to 98%
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Research Use Only